产品货号：
GS4490
中文名称：
重组人Noggin
英文名称：
Recombinant Human Noggin
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 46.3kDa,non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
储存条件：冷冻（-20℃）
概述
Noggin encoded by the NOG gene,was first isolated from Xenopus,having the function of inducing secondary axis formation in frog embryos.It inhibits TGF-β family ligands and preventing them from binding to their corresponding receptors.Noggin was originally found as a BMP-4 antagonist,and then has been shown to modulate the activities of other BMPs(BMP-2,7,13 and 14).Additionally,it has pleiotropic effect,both in early development and later stages.The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes,such as neural tube fusion and joint formation.In recent report,proximal symphalangism(SYM1)and multiple synostoses syndrome(SYNS1)have relation with the mutant of evolutionarily conserved amino acid residues of Noggin.Mature human Noggin shares 99%,99%,98%,97%and 89%a.a.sequence identity with mouse,rat,bovine,equine and chicken Noggin,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人Noggin，Noggin, Human，Recombinant Human Noggin
储存条件：冷冻（-20℃）
概述
Noggin encoded by the NOG gene,was first isolated from Xenopus,having the function of inducing secondary axis formation in frog embryos.It inhibits TGF-β family ligands and preventing them from binding to their corresponding receptors.Noggin was originally found as a BMP-4 antagonist,and then has been shown to modulate the activities of other BMPs(BMP-2,7,13 and 14).Additionally,it has pleiotropic effect,both in early development and later stages.The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes,such as neural tube fusion and joint formation.In recent report,proximal symphalangism(SYM1)and multiple synostoses syndrome(SYNS1)have relation with the mutant of evolutionarily conserved amino acid residues of Noggin.Mature human Noggin shares 99%,99%,98%,97%and 89%a.a.sequence identity with mouse,rat,bovine,equine and chicken Noggin,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by inhibiting BMP-4-induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0ng/ml,corresponding to a specific activity of>3.3×105 IU/mg in the presence of 5 ng/ml rHuBMP-4. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 30%acetonitrile,0.1%TFA. |
| 内毒素 | Less than 1 EU/μg of rHuNoggin as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in 10mMHAc to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC |
相关搜索：重组人Noggin，Noggin, Human，Recombinant Human Noggin